Peroxicats: PEROXidases as bioCATalystS
Publications
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Total publications 80. Click in every publication for more information.
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2012
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Yarman A, Gröbe G, Neumann B, Kinne M, Gajovic-Eichelmann N, Wollenberger U, Hofrichter M, Ullrich R, Scheibner K, Scheller FW (2012). "The aromatic peroxygenase from Marasmius rutola--a new enzyme for biosensor applications". Anal. Bioanal. Chem., 402: 405-412.
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2011
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Barková K, Kinne M, Ullrich R, Hennig L, Fuchs A, Hofrichter M (2011). "Regioselective hydroxylation of diverse flavonoids by an aromatic peroxygenase". Tetrahedron, 67: 4874-4878.
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Bernini C, Pogni R, Ruiz-Dueñas FJ, Martínez AT, Basosi R, Sinicropi A (2011). "EPR parameters of amino acid radicals in P. eryngii versatile peroxidase and its W164Y variant computed at the QM/MM level". Phys. Chem. Chem. Phys., 13: 5078-5098.
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Gröbe G, Ullrich R, Pecyna MJ, Kapturska D, Friedrich S, Hofrichter M, Scheibner K (2011). "High-yield production of aromatic peroxygenase by the agaric fungus Marasmius rotula". AMB Express, 1: 31-42.
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Gutiérrez A, Babot ED, Ullrich R, Hofrichter M, Martínez AT, del Río JC (2011). "Regioselective oxygenation of fatty acids, fatty alcohols and other aliphatic compounds by a basidiomycete heme-thiolate peroxidase". Arch. Biochem. Biophys., 541: 33-43.
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Hernández-Ortega A, Borrelli K, Ferreira P, Medina M, Martínez AT, Guallar V (2011). "Substrate diffusion and oxidation in GMC oxidoreductases: an experimental and computational study on fungal aryl-alcohol oxidase". Biochem. J., 431: 341-350.
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Hernández-Ortega A, Lucas F, Ferreira P, Medina M, Guallar V, Martínez AT (2011). "Modulating O2 reactivity in a fungal flavoenzyme: Involvement of aryl-alcohol oxidase Phe-501 contiguous to catalytic histidine". J. Biol. Chem., 286: 41105-41114.
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Kinne M, Poraj-Kobielska M, Ullrich R, Nousiainen P, Sipilä J, Scheibner K, Hammel KE, Hofrichter M (2011). "Oxidative cleavage of non-phenolic β-O-4 lignin model dimers by an extracellular aromatic peroxygenase". Holzforschung, doi: 10.1515/HF.2011.057.
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Liers C, Arnstadt T, Ullrich R, Hofrichter M (2011). "Patterns of lignin degradation and oxidative enzyme secretion by different wood- and litter-colonizing basidiomycetes and ascomycetes grown on beech wood". FEMS Microbiol. Ecol., 78: 91-102.
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Liers C, Ullrich R, Hofrichter M, Minibayeva F, Beckett RP (2011). "A heme peroxidase of the ascomyceteous lichen Leptogium saturninum oxidizes high-redox potential substrates". Fungal Gen. Biol., 48: 1139-11.
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Marques G, Molina S, Babot ED, Lund H, del Río JC, Gutiérrez A (2011). "Exploring the potential of fungal manganese-containing lipoxygenase for pitch control and pulp delignification". Bioresource Technol., 102: 1338-1343.
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Martínez AT, Rencoret J, Nieto L, Jiménez-Barbero J, Gutiérrez A, del Río JC (2011). "Selective lignin and polysaccharide removal in natural fungal decay of wood as evidenced by in situ structural analyses". Environ. Microbiol., 13: 96-107.
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Miki Y, Calviño FR, Pogni R, Giansanti S, Ruiz-Dueñas FJ, Martínez MJ, Basosi R, Romero A, Martínez AT (2011). "Crystallographic, kinetic, and spectroscopic study of the first ligninolytic peroxidase presenting a catalytic tyrosine". J. Biol. Chem., 286: 15525-15534.
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Peter S, Kinne M, Wang X, Ullrich R, Kayser G, Groves JT, Hofrichter M (2011). "Selective hydroxylation of alkanes by an extracellular fungal peroxygenase". FEBS J., 278: 3667-3675.
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Rencoret J, Gutiérrez A, Nieto L, Jiménez-Barbero J, Faulds CB, Kim H, Ralph J, Martínez AT, del Río JC (2011). "Lignin composition and structure in young versus adult Eucalyptus globulus plants". Plant Physiol., 155: 667-682.
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Ruiz-Dueñas FJ, Fernandez-Fueyo E, Martínez MJ, Martínez AT (2011). "Pleurotus ostreatus heme peroxidases: An in silico analysis from the genome sequence to the enzyme molecular structure". C. R. Biologies, 334: 795-805.
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2010
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Aranda E, Ullrich R, Hofrichter M (2010). "Conversion of polycyclic aromatic hydrocarbons, methyl naphthalenes and dibenzofuran by two fungal peroxygenases". Biodegradation, 21: 267-281.
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Ferreira P, Hernández-Ortega A, Herguedas B, Rencoret J, Gutiérrez A, Martínez MJ, Jiménez-Barbero J, Medina M, Martínez AT (2010). "Kinetic and chemical characterization of aldehyde oxidation by fungal aryl-alcohol oxidase". Biochem. J., 425: 585-593.
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García-Ruiz E, Maté D, Ballesteros A, Martínez AT, Alcalde M (2010). "Evolving thermostability in mutant libraries of ligninolytic oxidoreductases expressed in yeast". Microb. Cell Fact., 9: 17-29.
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Gutiérrez A, del Río JC, Martínez AT (2010). "Fungi and Their Enzymes for Pitch Control in the Pulp and Paper Industry". The Mycota, 10: 357-377.
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Expected impacts of Peroxicats
The impacts from the use of the novel and robust peroxidases/peroxygenases developed in PEROXICATS will concern the European Biotechnology, Bulk and Fine Chemicals (including Pharmaceuticals) sectors. The European chemical industry already maintains a top position at the world level, but during the last years it has lost its first place in the ranking to Asia (China and Japan included) according to the 2009 Annual Report of CEFIC, the European Chemical Industry Council. In organic synthesis, specific oxidation/oxygenation reactions still represent a challenging area, both in synthesis or production of bulk chemicals as in the specialties and pharmaceutical sector. As stated in an EuropaBio/ESAB report on sustainable industrial development in the EU, White Biotechnology should be one of the pillars to maintain the leading position of the chemical industry in Europe by both identifying/engineering specific enzymes for obtaining complex molecules for speciality chemicals and by improving the efficiency (rather than the novelty) of the production process.

The new peroxidases/peroxygenases from PEROXICATS will be of interest in these two industrial sectors. The following examples give an idea of their potential use in different industrial applications:
- Oxygenation/hydroxylation of aromatic bulk hydrocarbons
- Oxyfunctionalization of various bioactive molecules (drugs, pesticides, etc)
- Plant cell-wall delignification
- Enzyme-assisted bleaching of paper pulp
- Functionalization of natural fibres
- Production of flavours for food and beverages
- Production of adhesives and (food and non-food) biomaterials
- Modification of lignin
- Removal of protecting groups in chemical synthesis by O- and N-dealkylation
- Degradation of phenolic and non-phenolic aromatic pollutants
- Degradation of high redox-potential and polymeric dyes
- Degradation of polycyclic aromatic hydrocarbons, pesticides, dioxins, chlorophenols and explosives
- Organic synthesis (selective oxidative coupling: C-C, C-N, C-S)
- Production of polymers
- Production of biologically active compounds (antibiotics, derivatization of amino acids, etc)

protein purification
Protein purification. Foto: R. Ulrich.
eu Official website of peroxicats [Peroxidases as biocatalysts]. Novel and more robust fungal peroxidases as industrial biocatalysts. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under Grant Agreement nº: KBBE-2010-4-265397. © Peroxicats 2011. Developed by Shunet. This site is optimized for the following versions and browsers: Internet Explorer 8 or higher, Firefox 3.6 or higher, Safari 5 or higher, Google Chrome 10 or higher and Opera 10.10 or higher.